Protein D, a putative immunoglobulin D-binding protein produced by Haemophilus influenzae, is glycerophosphodiester phosphodiesterase
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چکیده
منابع مشابه
Protein D, the immunoglobulin D-binding protein of Haemophilus influenzae, is a lipoprotein.
Protein D is an immunoglobulin D-binding membrane protein exposed on the surface of the gram-negative bacterium Haemophilus influenzae. Results reported here indicate that protein D is a lipoprotein. The protein is apparently synthesized as a precursor with an 18-residue-long signal sequence modified by the covalent attachment of both ester-linked and amide-linked palmitate to the cysteine resi...
متن کاملProtein D of Haemophilus influenzae is not a universal immunoglobulin D-binding protein.
Haemophilus influenzae type b and nontypeable H. influenzae have been reported to bind human immunoglobulin D (IgD). IgD myeloma sera from five patients were tested for the ability of IgD to bind to H. influenzae. Serotype b strains bound human IgD in four of the five sera tested. IgD in the fifth serum bound strongly to type b strain MinnA but poorly to other type b strains. Additionally, IgD ...
متن کاملProtein D, the glycerophosphodiester phosphodiesterase from Haemophilus influenzae with affinity for human immunoglobulin D, influences virulence in a rat otitis model.
A mutant lacking the ability to express the surface-exposed lipoprotein protein D was constructed by linker insertion and deletion mutagenesis of a cloned DNA insert containing the protein D structural gene from a nontypeable Haemophilus influenzae strain (NTHi). An isogenic NTHi mutant was isolated after transformation of genetically competent bacteria. The transformant was unreactive to a pro...
متن کاملHaemophilus influenzae resides in tonsils and uses immunoglobulin D binding as an evasion strategy.
Haemophilus influenzae (Hi) causes respiratory tract infections and is also considered to be a commensal, particularly in preschool children. Tonsils from patients (n = 617) undergoing tonsillectomy due to chronic infection or hypertrophy were examined. We found that 51% of tonsils were positive for Hi, and in 95% of cases analyzed in detail (n = 39) Hi resided intracellularly in the core tonsi...
متن کاملStructure of HI1333 (YhbY), a putative RNA-binding protein from Haemophilus influenzae.
Structure of HI1333 (YhbY), a putative RNA-binding protein from Haemophilus influenzae. Title Structure of HI1333 (YhbY), a putative RNA-binding protein from Haemophilus influenzae. Publication Type Journal Article Year of Publication 2002 Authors Willis, MA, Krajewski, W, Chalamasetty, VRao, Reddy, P, Howard, A, Herzberg, O Journal Proteins Volume 49 Issue 3 Pagination 423-6 Date Published 200...
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ژورنال
عنوان ژورنال: Journal of Bacteriology
سال: 1993
ISSN: 0021-9193,1098-5530
DOI: 10.1128/jb.175.14.4569-4571.1993